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HomoloGene:18125. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GPBAR1,  H.sapiens
G protein-coupled bile acid receptor 1
    NP_001070659.1
330 aa
   GPBAR1,  P.troglodytes
G protein-coupled bile acid receptor 1
    XP_001155488.1
330 aa
   GPBAR1,  M.mulatta
G protein-coupled bile acid receptor 1
    XP_001088918.1
330 aa
   GPBAR1,  C.lupus
G protein-coupled bile acid receptor 1
    XP_005640698.1
330 aa
   GPBAR1,  B.taurus
G protein-coupled bile acid receptor 1
    NP_778219.1
329 aa
   Gpbar1,  M.musculus
G protein-coupled bile acid receptor 1
    NP_778150.1
329 aa
   Gpbar1,  R.norvegicus
G protein-coupled bile acid receptor 1
    NP_808797.1
329 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The TGR5 receptor mediates bile acid-induced itch and analgesia.
Alemi F, et al. J Clin Invest 123, 1513-30 (2013).
Expression of bile acid receptor TGR5 in gastric adenocarcinoma.
Cao W, et al. Am J Physiol Gastrointest Liver Physiol 304, G322-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gpbar1 includes H.sapiens GPBAR1 and R.norvegicus Gpbar1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)

 

 

 

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