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HomoloGene:11026. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   OTX2,  H.sapiens
orthodenticle homeobox 2
297 aa
   OTX2,  P.troglodytes
orthodenticle homeobox 2
297 aa
   OTX2,  C.lupus
orthodenticle homeobox 2
297 aa
   OTX2,  B.taurus
orthodenticle homeobox 2
289 aa
   Otx2,  M.musculus
orthodenticle homolog 2
297 aa
   LOC100911492,  R.norvegicus
homeobox protein OTX2-like
297 aa
   otx2,  D.rerio
orthodenticle homolog 2
289 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Microphthalmia, syndromic 5.

Articles associated with genes and sequences of this homology group.

Gene dosage of Otx2 is important for fertility in male mice.
Larder R, et al. Mol Cell Endocrinol 377, 16-22 (2013).
Autosomal dominant oculoauriculovertebral spectrum and 14q23.1 microduplication.
Ballesta-Martínez MJ, et al. Am J Med Genet A 161A, 2030-5 (2013).
Brain development is a multi-level regulated process--the case of the OTX2 gene.
Gat-Yablonski G. Pediatr Endocrinol Rev 9, 422-30 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TF_Otx (pfam03529)
  Otx1 transcription factor.
TF_Otx (pfam03529)
  Otx1 transcription factor.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Otx2 includes H.sapiens OTX2 and R.norvegicus Otx2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Insecta - insects (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)

Chromadorea - nematodes (1 transcript, 1 species)




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