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HomoloGene:14583. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FLCN,  H.sapiens
folliculin
    NP_659434.2
579 aa
   FLCN,  P.troglodytes
folliculin
    XP_001161086.1
342 aa
   FLCN,  M.mulatta
folliculin
    XP_001088928.1
579 aa
   FLCN,  C.lupus
folliculin
    NP_001121083.1
579 aa
   FLCN,  B.taurus
folliculin
    NP_001030440.1
579 aa
   Flcn,  M.musculus
folliculin
    NP_001258285.1
579 aa
   Flcn,  R.norvegicus
folliculin
    NP_955422.1
579 aa
   FLCN,  G.gallus
folliculin
    XP_414807.2
579 aa
   flcn,  X.tropicalis
folliculin
    NP_001011353.1
579 aa
   flcn,  D.rerio
folliculin
    NP_001035463.1
558 aa
   BHD,  D.melanogaster
Birt-Hogg-Dube homolog
    NP_648090.1
460 aa
   AgaP_AGAP007579,  A.gambiae
AgaP_AGAP007579
    XP_308295.3
478 aa
   F22D3.2,  C.elegans
F22D3.2
    NP_001022107.2
638 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Colorectal cancer, somatic.
Birt-Hogg-Dube syndrome.
Renal carcinoma, chromophobe, somatic.
Pneumothorax, primary spontaneous.



Publications
Articles associated with genes and sequences of this homology group.

Birt-Hogg-Dube syndrome is a novel ciliopathy.
Luijten MN, et al. Hum Mol Genet 22, 4383-97 (2013).
Gene expression and protein array studies of folliculin-regulated pathways.
Reiman A, et al. Anticancer Res 32, 4663-70 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Folliculin (pfam11704)
  Vesicle coat protein involved in Golgi to plasma membrane transport.
Folliculin (pfam11704)
  Vesicle coat protein involved in Golgi to plasma membrane transport.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Flcn includes H.sapiens FLCN and R.norvegicus Flcn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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