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HomoloGene:462. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TSC2,  H.sapiens
tuberous sclerosis 2
    NP_000539.2
1807 aa
   TSC2,  P.troglodytes
tuberous sclerosis 2
    XP_523477.3
1803 aa
   TSC2,  M.mulatta
tuberous sclerosis 2
    XP_001083256.1
1807 aa
   TSC2,  C.lupus
tuberous sclerosis 2
    XP_852047.2
1815 aa
   TSC2,  B.taurus
tuberous sclerosis 2
    XP_003587856.2
1965 aa
   Tsc2,  M.musculus
tuberous sclerosis 2
    NP_001034452.1
1742 aa
   Tsc2,  R.norvegicus
tuberous sclerosis 2
    NP_036812.2
1809 aa
   TSC2,  G.gallus
tuberous sclerosis 2
    XP_003642168.2
1891 aa
   tsc2,  X.tropicalis
tuberous sclerosis 2
    NP_001123795.1
1753 aa
   tsc2,  D.rerio
tuberous sclerosis 2
    XP_695912.6
1226 aa
   gig,  D.melanogaster
gigas
    NP_524177.1
1847 aa
   AgaP_AGAP011123,  A.gambiae
AgaP_AGAP011123
    XP_309523.4
2004 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Tuberous sclerosis-2.
Lymphangioleiomyomatosis, somatic.



Publications
Articles associated with genes and sequences of this homology group.

Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration.
Obayashi Y, et al. Biochem Biophys Res Commun 437, 146-50 (2013).
Bilateral keratoconus in tuberous sclerosis: is there a molecular link?
Lyall DA, et al. Can J Ophthalmol 47, e41-2 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Rap_GAP (pfam02145)
  Rap/ran-GAP.
DUF3384 (pfam11864)
  Domain of unknown function (DUF3384).
Rap_GAP (pfam02145)
  Rap/ran-GAP.
DUF3384 (pfam11864)
  Domain of unknown function (DUF3384).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tsc2 includes H.sapiens TSC2 and R.norvegicus Tsc2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 12 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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