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HomoloGene:68226. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GSPT1,  H.sapiens
G1 to S phase transition 1
    NP_001123478.1
636 aa
   GSPT1,  P.troglodytes
G1 to S phase transition 1
    XP_001140542.3
346 aa
   LOC716860,  M.mulatta
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
    XP_001107851.2
870 aa
   GSPT1,  C.lupus
G1 to S phase transition 1
    XP_005621589.1
498 aa
   GSPT1,  B.taurus
G1 to S phase transition 1
    NP_001091540.2
636 aa
   Gspt1,  M.musculus
G1 to S phase transition 1
    NP_001123480.1
635 aa
   Gspt1,  R.norvegicus
G1 to S phase transition 1
    NP_001003978.1
636 aa
   LOC100911685,  R.norvegicus
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
    XP_006245802.1
636 aa
   GSPT1,  G.gallus
G1 to S phase transition 1
    NP_001129149.1
618 aa
   gspt1,  X.tropicalis
G1 to S phase transition 1
    NP_001015805.2
573 aa
   gspt1l,  D.rerio
G1 to S phase transition 1, like
    NP_942101.1
577 aa
   gspt1,  D.rerio
G1 to S phase transition 1
    NP_001003992.1
564 aa
   Elf,  D.melanogaster
Ef1alpha-like factor
    NP_001260415.1
619 aa
   AgaP_AGAP009310,  A.gambiae
AgaP_AGAP009310
    XP_320105.3
478 aa
   SUP35,  S.cerevisiae
SUP35
    NP_010457.3
685 aa
   KLLA0D17424g,  K.lactis
KLLA0D17424g
    XP_453831.1
700 aa
   AGOS_AGL145W,  E.gossypii
AGOS_AGL145W
    NP_986522.2
691 aa
   sup35,  S.pombe
sup35
    NP_588225.1
662 aa
   MGG_00449,  M.oryzae
MGG_00449
    XP_003718618.1
731 aa
   NCU04790,  N.crassa
NCU04790
    XP_960416.1
730 aa
   AT1G18070,  A.thaliana
AT1G18070
    NP_001185026.1
543 aa
   Os04g0270100,  O.sativa
Os04g0270100
    NP_001052341.1
444 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Ion-specific effects on prion nucleation and strain formation.
Rubin J, et al. J Biol Chem 288, 30300-8 (2013).
The [PSI+] prion exists as a dynamic cloud of variants.
Bateman DA & Wickner RB. PLoS Genet 9, e1003257 (2013).
[PSI(+) ] prion variant establishment in yeast.
Sharma J & Liebman SW. Mol Microbiol 86, 866-81 (2012).
Effect of electrostatics on aggregation of prion protein Sup35 peptide.
Portillo AM, et al. J Phys Condens Matter 24, 164205 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PAM2 (pfam07145)
  Ataxin-2 C-terminal region.
BASP1 (pfam05466)
  Brain acid soluble protein 1 (BASP1 protein).
PAM2 (pfam07145)
  Ataxin-2 C-terminal region.
DUF1720 (pfam08226)
  Domain of unknown function (DUF1720).
Translation_factor_III (cl02786)
  Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu ...
Translation_Factor_II_like (cl02787)
  Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to ...
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gspt1 includes H.sapiens GSPT1 and R.norvegicus Gspt1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (29 transcripts, 10 species)
Mammalia - mammals (26 transcripts, 15 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 12 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (49 transcripts, 31 species)
Liliopsida - monocots (15 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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