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HomoloGene:10664. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ANKH,  H.sapiens
ANKH inorganic pyrophosphate transport regulator
    NP_473368.1
492 aa
   ANKH,  P.troglodytes
ankylosis, progressive homolog (mouse)
    XP_003310678.1
492 aa
   ANKH,  M.mulatta
ankylosis, progressive homolog (mouse)
    XP_002804357.1
492 aa
   ANKH,  C.lupus
ANKH inorganic pyrophosphate transport regulator
    XP_005619485.1
513 aa
   ANKH,  B.taurus
ankylosis, progressive homolog (mouse)
    NP_001103263.1
492 aa
   Ank,  M.musculus
progressive ankylosis
    NP_065065.3
492 aa
   Ankh,  R.norvegicus
ANKH inorganic pyrophosphate transport regulator
    NP_446166.1
492 aa
   ANKH,  G.gallus
ankylosis, progressive homolog (mouse)
    NP_001012580.1
493 aa
   ankh,  X.tropicalis
ankylosis, progressive homolog (mouse)
    XP_002933168.1
492 aa
   ankhb,  D.rerio
ankylosis, progressive homolog b
    NP_919351.1
501 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Chondrocalcinosis 2.
Craniometaphyseal dysplasia.



Publications
Articles associated with genes and sequences of this homology group.

Otological aspects and surgical outcome in a consanguineous family with a novel ANKH gene mutation.
Thomeer HG, et al. Int J Pediatr Otorhinolaryngol 77, 1152-7 (2013).
ANKH and susceptibility to and severity of ankylosing spondylitis.
Pimentel-Santos FM, et al. J Rheumatol 39, 131-4 (2012).
Investigating ANKH and ENPP1 in Slovakian families with chondrocalcinosis.
Couto AR, et al. Rheumatol Int 32, 2745-51 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ANKH (pfam07260)
  Progressive ankylosis protein (ANKH).
MATE_like (cl09326)
  Multidrug and toxic compound extrusion family and similar proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ank includes H.sapiens ANKH and R.norvegicus Ankh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 8 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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