Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:37423. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RYR2,  H.sapiens
ryanodine receptor 2 (cardiac)
    NP_001026.2
4967 aa
   RYR2,  P.troglodytes
ryanodine receptor 2 (cardiac)
    XP_514296.4
5019 aa
   RYR2,  M.mulatta
ryanodine receptor 2-like
    XP_002808310.1
4985 aa
   RYR2,  C.lupus
ryanodine receptor 2 (cardiac)
    XP_005618836.1
4976 aa
   LOC537376,  B.taurus
ryanodine receptor 2-like
    XP_005226298.1
4975 aa
   Ryr2,  M.musculus
ryanodine receptor 2, cardiac
    NP_076357.2
4966 aa
   Ryr2,  R.norvegicus
ryanodine receptor 2, cardiac
    NP_114467.1
4953 aa
   RYR2,  G.gallus
ryanodine receptor 2 (cardiac)
    XP_419553.4
4965 aa
   ryr1,  X.tropicalis
ryanodine receptor 1 (skeletal)
    XP_004917163.1
5034 aa
   ryr1b,  D.rerio
ryanodine receptor 1b (skeletal)
    NP_001096041.1
5076 aa
   ryr1a,  D.rerio
ryanodine receptor 1a (skeletal)
    XP_001923294.4
5018 aa
   Rya-r44F,  D.melanogaster
Ryanodine receptor 44F
    NP_001246207.1
5117 aa
   AgaP_AGAP010750,  A.gambiae
AgaP_AGAP010750
    XP_318561.3
5109 aa
   unc-68,  C.elegans
unc-68
    NP_001256074.1
5333 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Arrhythmogenic right ventricular dysplasia 2.
Ventricular tachycardia, stress-induced polymorphic.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RyR (pfam02026)
  RyR domain.
YjfB_motility (pfam14070)
  Putative motility protein.
Ion_trans (pfam00520)
  Ion transport protein.
RYDR_ITPR (pfam01365)
  RIH domain.
MIR (pfam02815)
  MIR domain.
RR_TM4-6 (pfam06459)
  Ryanodine Receptor TM 4-6.
RIH_assoc (pfam08454)
  RyR and IP3R Homology associated.
EF_hand_5 (pfam13499)
  EF-hand domain pair.
EF_hand_6 (pfam13833)
  EF-hand domain pair.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Ion_trans (pfam00520)
  Ion transport protein.
RYDR_ITPR (pfam01365)
  RIH domain.
RyR (pfam02026)
  RyR domain.
MIR (pfam02815)
  MIR domain.
RR_TM4-6 (pfam06459)
  Ryanodine Receptor TM 4-6.
RIH_assoc (pfam08454)
  RyR and IP3R Homology associated.
YjfB_motility (pfam14070)
  Putative motility protein.
SPRY (cl02614)
  SPRY domain.
Ins145_P3_rec (cl19745)
  Inositol 1,4,5-trisphosphate/ryanodine receptor.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ryr2 includes H.sapiens RYR2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (28 transcripts, 12 species)
Actinopterygii - bony fishes (19 transcripts, 4 species)
Aves - birds (6 transcripts, 3 species)
Cephalochordata - lancelets (3 transcripts, 1 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Maxillopoda - crustaceans (3 transcripts, 1 species)
Arachnida - arachnids (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

 

 

 

Write to the Help Desk