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HomoloGene:55427. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   ANK1,  H.sapiens
ankyrin 1, erythrocytic
1897 aa
   ANK1,  P.troglodytes
ankyrin 1, erythrocytic
1880 aa
   ANK1,  M.mulatta
ankyrin 1, erythrocytic
1947 aa
   ANK1,  C.lupus
ankyrin 1, erythrocytic
1916 aa
   ANK1,  B.taurus
ankyrin 1, erythrocytic
1968 aa
   Ank1,  M.musculus
ankyrin 1, erythroid
1907 aa
   Ank1,  R.norvegicus
ankyrin 1, erythrocytic
1707 aa
   ANK1,  G.gallus
ankyrin 1, erythrocytic
2201 aa
   si:ch211-263m18.3,  D.rerio
1886 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.


Articles associated with genes and sequences of this homology group.

Ankyrin is a target of spectrin's E2/E3 ubiquitin-conjugating/ligating activity.
Chang TL, et al. Cell Mol Biol (Noisy-le-grand) 50, 59-66 (2004).
Crystal structure of a 12 ANK repeat stack from human ankyrinR.
Michaely P, et al. EMBO J 21, 6387-96 (2002).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Death_ank1 (cd08805)
  Death domain of Ankyrin-1.
ZU5 (cl02517)
  ZU5 domain.
Ank (pfam00023)
  Ankyrin repeat.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_5 (pfam13857)
  Ankyrin repeats (many copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
Ank_5 (cl02529)
  Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ank1 includes H.sapiens ANK1 and R.norvegicus Ank1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 7 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 1 species)

Eudicotyledons - eudicots (10 transcripts, 10 species)
Liliopsida - monocots (1 transcript, 1 species)

Pezizomycetes - ascomycetes (3 transcripts, 1 species)




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