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HomoloGene:50038. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CASP10,  H.sapiens
caspase 10, apoptosis-related cysteine peptidase
    NP_116759.2
522 aa
   CASP10,  P.troglodytes
caspase 10, apoptosis-related cysteine peptidase
    XP_003949992.1
520 aa
   CASP10,  M.mulatta
caspase 10, apoptosis-related cysteine peptidase
    XP_001097804.2
481 aa
   CASP10,  C.lupus
caspase 10, apoptosis-related cysteine peptidase
    XP_005640587.1
480 aa
   CASP10,  G.gallus
caspase 10, apoptosis-related cysteine peptidase
    XP_421936.4
537 aa
   casp10,  X.tropicalis
caspase 10, apoptosis-related cysteine peptidase
    NP_001015715.2
519 aa
   casp8l2,  D.rerio
caspase 8, apoptosis-related cysteine peptidase, like 2
    XP_685430.4
520 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Gastric cancer, somatic.
Autoimmune lymphoproliferative syndrome, type II.
Non-Hodgkin lymphoma, somatic.



Publications
Articles associated with genes and sequences of this homology group.

Control of autophagic cell death by caspase-10 in multiple myeloma.
Lamy L, et al. Cancer Cell 23, 435-49 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DED_Caspase_10_repeat2 (cd08814)
  Death Effector Domain, repeat 2, of Caspase-10.
DED_Caspase_8_10_repeat2 (cd08334)
  Death effector domain, repeat 2, of initator caspases 8 and 10.
DED_Caspase_10_repeat1 (cd08341)
  Death effector domain, repeat 1, of Caspase-10.
DED_Caspase_8_10_repeat1 (cd08792)
  Death effector domain, repeat 1, of initator caspases 8 and 10.
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
CASc (cl00042)
  Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

 

 

 

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