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HomoloGene:22558. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   DLX1,  H.sapiens
distal-less homeobox 1
255 aa
   DLX1,  P.troglodytes
distal-less homeobox 1
255 aa
   DLX1,  M.mulatta
distal-less homeobox 1
255 aa
   DLX1,  C.lupus
distal-less homeobox 1
255 aa
   DLX1,  B.taurus
distal-less homeobox 1
255 aa
   Dlx1,  M.musculus
distal-less homeobox 1
255 aa
   Dlx1,  R.norvegicus
distal-less homeobox 1
255 aa
   DLX1,  G.gallus
distal-less homeobox 1
255 aa
   dlx1,  X.tropicalis
distal-less homeobox 1
251 aa
   dlx1a,  D.rerio
distal-less homeobox gene 1a
252 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.
Seybold BA, et al. Proc Natl Acad Sci U S A 109, 13829-34 (2012).
Severe hearing loss in Dlxl mutant mice.
Polley DB, et al. Hear Res 214, 84-8 (2006).
Analysis of four DLX homeobox genes in autistic probands.
Hamilton SP, et al. BMC Genet 6, 52 (2005).
Mammalian Dlx homeobox gene control of craniofacial and inner ear morphogenesis.
Kraus P & Lufkin T. J Cell Biochem Suppl 32-33, 133-40 (1999).
The DLX1and DLX2 genes and susceptibility to autism spectrum disorders.
Liu X, et al. Eur J Hum Genet 17, 228-35 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dlx1 includes H.sapiens DLX1 and R.norvegicus Dlx1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 7 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arachnida - arachnids (2 transcripts, 1 species)




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