Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:31189. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TP63,  H.sapiens
tumor protein p63
    NP_003713.3
680 aa
   TP63,  P.troglodytes
tumor protein p63
    XP_001160376.1
680 aa
   TP63,  M.mulatta
tumor protein p63
    XP_001092093.1
680 aa
   TP63,  C.lupus
tumor protein p63
    XP_850415.3
680 aa
   TP63,  B.taurus
tumor protein p63
    NP_001178266.1
680 aa
   Trp63,  M.musculus
transformation related protein 63
    NP_001120731.1
680 aa
   Tp63,  R.norvegicus
tumor protein p63
    NP_062094.1
680 aa
   TP63,  G.gallus
tumor protein p63
    NP_989682.1
582 aa
   tp63,  X.tropicalis
tumor protein p63
    XP_002934096.2
643 aa
   tp63,  D.rerio
tumor protein p63
    NP_689454.1
576 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
ADULT syndrome.
Hay-Wells syndrome.
Orofacial cleft 8.
Rapp-Hodgkin syndrome.
Limb-mammary syndrome.
Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3.
Split-hand/foot malformation, type 4.



Publications
Articles associated with genes and sequences of this homology group.

An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome.
Vernersson Lindahl E, et al. Am J Med Genet A 161A, 1961-71 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P53_tetramer (pfam07710)
  P53 tetramerisation motif.
P53 (cl14608)
  P53 DNA-binding domain.
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
P53_tetramer (pfam07710)
  P53 tetramerization motif.
Fork_head_N (pfam08430)
  Forkhead N-terminal region.
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trp63 includes H.sapiens TP63 and R.norvegicus Tp73l.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

 

 

 

Write to the Help Desk