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HomoloGene:36321. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TIMP1,  H.sapiens
TIMP metallopeptidase inhibitor 1
207 aa
   TIMP1,  M.mulatta
TIMP metallopeptidase inhibitor 1
207 aa
   TIMP1,  C.lupus
TIMP metallopeptidase inhibitor 1
207 aa
   TIMP1,  B.taurus
TIMP metallopeptidase inhibitor 1
207 aa
   Timp1,  M.musculus
tissue inhibitor of metalloproteinase 1
205 aa
   Timp1,  R.norvegicus
TIMP metallopeptidase inhibitor 1
217 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

The TIMP-1 expression in germinal centers of hypertrophied adenoids in children.
Musiatowiwcz M, et al. Int J Pediatr Otorhinolaryngol 77, 384-8 (2013).
Plasma TIMP1 level is a prognostic factor in patients with liver metastases.
Bunatova K, et al. Anticancer Res 32, 4601-6 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NTR_like (cl02512)
  NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Timp1 includes H.sapiens TIMP1 and R.norvegicus Timp1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (15 transcripts, 15 species)

Coccidia - apicomplexans (1 transcript, 1 species)




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