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HomoloGene:16. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ALAD,  H.sapiens
aminolevulinate dehydratase
    NP_000022.3
330 aa
   ALAD,  P.troglodytes
aminolevulinate dehydratase
    XP_001152445.2
339 aa
   ALAD,  M.mulatta
aminolevulinate dehydratase
    XP_001101576.1
339 aa
   ALAD,  C.lupus
aminolevulinate dehydratase
    XP_855370.1
330 aa
   ALAD,  B.taurus
aminolevulinate dehydratase
    NP_001014895.1
329 aa
   Alad,  M.musculus
aminolevulinate, delta-, dehydratase
    NP_032551.3
330 aa
   Alad,  R.norvegicus
aminolevulinate dehydratase
    NP_037031.1
330 aa
   HDHD3,  G.gallus
haloacid dehalogenase-like hydrolase domain containing 3
    XP_004945820.1
336 aa
   alad,  X.tropicalis
aminolevulinate dehydratase
    NP_001072186.1
330 aa
   alad,  D.rerio
aminolevulinate dehydratase
    NP_001017645.1
331 aa
   Pbgs,  D.melanogaster
Porphobilinogen synthase
    NP_648564.1
327 aa
   AgaP_AGAP010935,  A.gambiae
AgaP_AGAP010935
    XP_309759.4
328 aa
   HEM2,  S.cerevisiae
HEM2
    NP_011475.1
342 aa
   KLLA0F09273g,  K.lactis
KLLA0F09273g
    XP_455502.1
342 aa
   AGOS_AGR015C,  E.gossypii
AGOS_AGR015C
    NP_986680.1
340 aa
   hem2,  S.pombe
hem2
    NP_593917.1
329 aa
   MGG_10655,  M.oryzae
MGG_10655
    XP_003710087.1
389 aa
   NCU01013,  N.crassa
NCU01013
    XP_961625.1
385 aa
   HEMB1,  A.thaliana
HEMB1
    NP_001077800.1
430 aa
   Os06g0704600,  O.sativa
Os06g0704600
    NP_001058510.1
426 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Lead poisoning, susceptibility to.
Porphyria, acute hepatic.



Publications
Articles associated with genes and sequences of this homology group.

Delta-aminolevulinic dehydratase is a proteasome interacting protein.
Bardag-Gorce F & French SW. Exp Mol Pathol 91, 485-9 (2011).
Blood lead levels, ALAD gene polymorphisms, and mortality.
van Bemmel DM, et al. Epidemiology 22, 273-8 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ALAD_PBGS (cl00338)
  Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Alad includes H.sapiens ALAD and R.norvegicus Alad.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (14 transcripts, 10 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 9 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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