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HomoloGene:3273. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ERBB2,  H.sapiens
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
    NP_004439.2
1255 aa
   ERBB2,  P.troglodytes
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    XP_003315512.2
1255 aa
   ERBB2,  M.mulatta
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    XP_001090430.1
1255 aa
   ERBB2,  C.lupus
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    NP_001003217.1
1259 aa
   ERBB2,  B.taurus
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
    XP_003587474.1
1255 aa
   Erbb2,  M.musculus
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    NP_001003817.1
1256 aa
   Erbb2,  R.norvegicus
v-erb-b2 avian erythroblastic leukemia viral oncogene 2
    NP_058699.2
1259 aa
   ERBB2,  G.gallus
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
    NP_001038126.1
1235 aa
   erbb2,  X.tropicalis
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    XP_002940420.2
1316 aa
   erbb2,  D.rerio
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
    NP_956413.2
1275 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Gastric cancer, somatic.
Glioblastoma, somatic.
Ovarian cancer, somatic.
Adenocarcinoma of lung, somatic.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TM_EGFR-like (cl17045)
  Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases.
Recep_L_domain (pfam01030)
  Receptor L domain.
FU (cl00066)
  Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Recep_L_domain (pfam01030)
  Receptor L domain.
Barttin (pfam15462)
  Bartter syndrome, infantile, with sensorineural deafness (Barttin).
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Erbb2 includes H.sapiens ERBB2 and R.norvegicus Erbb2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Aves - birds (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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