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HomoloGene:1462. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   DSC3,  H.sapiens
desmocollin 3
896 aa
   DSC3,  P.troglodytes
desmocollin 3
896 aa
   DSC3,  C.lupus
desmocollin 2
1104 aa
   DSC3,  B.taurus
desmocollin 3
840 aa
   Dsc3,  M.musculus
desmocollin 3
896 aa
   Dsc3,  R.norvegicus
desmocollin 3
900 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Loss of Desmocollin 3 in skin tumor development and progression.
Chen J, et al. Mol Carcinog 51, 535-45 (2012).
Autoimmunity to desmocollin 3 in pemphigus vulgaris.
Mao X, et al. Am J Pathol 177, 2724-30 (2010).
Loss of desmocollin 3 in mice leads to epidermal blistering.
Chen J, et al. J Cell Sci 121, 2844-9 (2008).
Epigenetic silencing of DSC3 is a common event in human breast cancer.
Oshiro MM, et al. Breast Cancer Res 7, R669-80 (2005).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cadherin (pfam00028)
  Cadherin domain.
Cadherin_C (pfam01049)
  Cadherin cytoplasmic region.
CA_like (cl15786)
  Cadherin repeat-like domain.
Cadherin_C (pfam01049)
  Cadherin cytoplasmic region.
Cadherin_pro (cl07391)
  Cadherin prodomain like.
CA_like (cl15786)
  Cadherin repeat-like domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dsc3 includes H.sapiens DSC3 and R.norvegicus Dsc3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 6 species)




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