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HomoloGene:19080. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NLRP1,  H.sapiens
NLR family, pyrin domain containing 1
    NP_127497.1
1473 aa
   NLRP1,  P.troglodytes
NLR family, pyrin domain containing 1
    XP_001167200.2
1441 aa
   NLRP1,  M.mulatta
NLR family, pyrin domain containing 1
    NP_001107821.1
1475 aa
   NLRP1,  C.lupus
NLR family, pyrin domain containing 1
    XP_005619937.1
1432 aa
   NLRP1,  B.taurus
NLR family, pyrin domain containing 1
    XP_003587454.2
1410 aa
   Nlrp1b,  M.musculus
NLR family, pyrin domain containing 1B
    NP_001035786.1
1174 aa
   Nlrp1b,  R.norvegicus
NLR family, pyrin domain containing 1B
    XP_006246908.1
1120 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Systemic lupus erythematosus, vitiligo-related, susceptibility to, 1.
Vitiligo-associated multiple autoimmune disease susceptibility 1.



Publications
Articles associated with genes and sequences of this homology group.

The role of the NLRP1 gene in systemic sclerosis: a replication study.
Teruel M, et al. Clin Exp Rheumatol 31, 187-8 (2013).
Evidence of association of the NLRP1 gene with giant cell arteritis.
Serrano A, et al. Ann Rheum Dis 72, 628-30 (2013).
Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP.
Liao KC & Mogridge J. Infect Immun 81, 570-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pyrin_NALPs (cd08320)
  Pyrin death domain found in NALP proteins.
CARD_ASC_NALP1 (cd08330)
  Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins.
FIIND (pfam13553)
  Function to find.
AAA (smart00382)
  ATPases associated with a variety of cellular activities.
NACHT (pfam05729)
  NACHT domain.
LRR_RI (cd00116)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
LRR_RI (cl15309)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
FIIND (pfam13553)
  Function to find.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 3 species)

 

 

 

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