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HomoloGene:31310. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SMAD4,  H.sapiens
SMAD family member 4
    NP_005350.1
552 aa
   SMAD4,  P.troglodytes
SMAD family member 4
    XP_001155601.1
552 aa
   SMAD4,  M.mulatta
SMAD family member 4
    XP_001096658.1
552 aa
   SMAD4,  C.lupus
SMAD family member 4
    XP_005615451.1
552 aa
   SMAD4,  B.taurus
SMAD family member 4
    NP_001069677.1
553 aa
   Smad4,  M.musculus
SMAD family member 4
    NP_032566.2
551 aa
   Smad4,  R.norvegicus
SMAD family member 4
    NP_062148.1
552 aa
   smad4.1,  X.tropicalis
SMAD family member 4, gene 1
    XP_002934485.1
549 aa
   zmp:0000000768,  D.rerio
zmp:0000000768
    NP_001116172.1
547 aa
   Med,  D.melanogaster
Medea
    NP_524610.1
771 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Polyposis, juvenile intestinal.
Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome.
Pancreatic cancer.



Publications
Articles associated with genes and sequences of this homology group.

Effects of the Smad4 C324Y mutation on thyroid cell proliferation.
D'Inzeo S, et al. Int J Oncol 42, 1890-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF822 (pfam05687)
  Plant protein of unknown function (DUF822).
MH1 (cl00055)
  N-terminal Mad Homology 1 (MH1) domain.
MH2 (cl00056)
  C-terminal Mad Homology 2 (MH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Smad4 includes H.sapiens SMAD4 and R.norvegicus Smad4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (26 transcripts, 8 species)
Mammalia - mammals (14 transcripts, 11 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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