Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:3817. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CSF1R,  H.sapiens
colony stimulating factor 1 receptor
    NP_005202.2
972 aa
   CSF1R,  P.troglodytes
colony stimulating factor 1 receptor
    XP_003310972.1
952 aa
   CSF1R,  M.mulatta
colony stimulating factor 1 receptor
    XP_001107711.2
976 aa
   CSF1R,  C.lupus
colony stimulating factor 1 receptor
    XP_546306.2
967 aa
   CSF1R,  B.taurus
colony stimulating factor 1 receptor
    NP_001068871.2
964 aa
   Csf1r,  M.musculus
colony stimulating factor 1 receptor
    NP_001032948.2
977 aa
   Csf1r,  R.norvegicus
colony stimulating factor 1 receptor
    NP_001025072.1
1022 aa
   csf1r,  X.tropicalis
csf1r protein
    NP_001008181.1
935 aa
   csf1ra,  D.rerio
colony stimulating factor 1 receptor, a
    NP_571747.1
977 aa
   csf1rb,  D.rerio
colony stimulating factor 1 receptor, b
    XP_001919824.4
948 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myeloid malignancy, predisposition to.



Publications
Articles associated with genes and sequences of this homology group.

CSF1R mutations link POLD and HDLS as a single disease entity.
Nicholson AM, et al. Neurology 80, 1033-40 (2013).
Regulation of microglial proliferation during chronic neurodegeneration.
Gómez-Nicola D, et al. J Neurosci 33, 2481-93 (2013).
The CSF-1 receptor fashions the intestinal stem cell niche.
Akcora D, et al. Stem Cell Res 10, 203-12 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ig_2 (pfam13895)
  Immunoglobulin domain.
IG (smart00409)
  Immunoglobulin.
IG_like (smart00410)
  Immunoglobulin like.
Pkinase_Tyr (pfam07714)
  Protein tyrosine kinase.
Ig (cl11960)
  Immunoglobulin domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Csf1r includes H.sapiens CSF1R and R.norvegicus Csf1r.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

Write to the Help Desk