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HomoloGene:47906. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ESR1,  H.sapiens
estrogen receptor 1
    NP_001116212.1
595 aa
   ESR1,  P.troglodytes
estrogen receptor 1
    XP_003311598.1
595 aa
   ESR1,  M.mulatta
estrogen receptor 1
    XP_001097228.1
595 aa
   ESR1,  C.lupus
estrogen receptor 1
    XP_533454.2
596 aa
   ESR1,  B.taurus
estrogen receptor 1
    NP_001001443.1
596 aa
   Esr1,  M.musculus
estrogen receptor 1 (alpha)
    NP_031982.1
599 aa
   Esr1,  R.norvegicus
estrogen receptor 1
    NP_036821.1
600 aa
   ESR1,  G.gallus
estrogen receptor 1
    NP_990514.1
589 aa
   esr1,  X.tropicalis
estrogen receptor 1
    NP_988866.1
543 aa
   esr1,  D.rerio
estrogen receptor 1
    NP_694491.1
569 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Atherosclerosis, susceptibility to.
Breast cancer.
Estrogen resistance.
HDL response to hormone replacement, augmented.
Migraine, susceptibility to.
Myocardial infarction, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Activating ESR1 mutations in hormone-resistant metastatic breast cancer.
Robinson DR, et al. Nat Genet 45, 1446-51 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ESR1_C (pfam12743)
  Oestrogen-type nuclear receptor final C-terminal.
Oest_recep (pfam02159)
  Oestrogen receptor.
Oest_recep (pfam02159)
  Oestrogen receptor.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Esr1 includes H.sapiens ESR1 and R.norvegicus Esr1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

 

 

 

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