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HomoloGene:2467. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TOP1,  H.sapiens
topoisomerase (DNA) I
    NP_003277.1
765 aa
   TOP1,  P.troglodytes
topoisomerase (DNA) I
    XP_514649.2
765 aa
   TOP1,  M.mulatta
topoisomerase (DNA) I
    XP_001088021.1
767 aa
   TOP1,  C.lupus
topoisomerase (DNA) I
    XP_534420.3
770 aa
   TOP1,  B.taurus
topoisomerase (DNA) I
    NP_001193416.1
769 aa
   Top1,  M.musculus
topoisomerase (DNA) I
    NP_033434.2
767 aa
   Top1,  R.norvegicus
topoisomerase (DNA) I
    NP_072137.1
767 aa
   TOP1,  G.gallus
topoisomerase (DNA) I
    NP_990441.1
766 aa
   LOC100496521,  X.tropicalis
DNA topoisomerase 1-like
    XP_002932918.2
804 aa
   top1l,  D.rerio
topoisomerase (DNA) I, like
    NP_001037789.1
758 aa
   Top1,  D.melanogaster
Topoisomerase 1
    NP_001014742.1
974 aa
   AgaP_AGAP004078,  A.gambiae
AgaP_AGAP004078
    XP_003436707.1
581 aa
   top-1,  C.elegans
top-1
    NP_001021578.1
734 aa
   TOP1,  S.cerevisiae
TOP1
    NP_014637.1
769 aa
   KLLA0C06116g,  K.lactis
KLLA0C06116g
    XP_452470.1
785 aa
   AGOS_ACL008C,  E.gossypii
AGOS_ACL008C
    NP_983396.2
732 aa
   top1,  S.pombe
top1
    NP_596209.1
814 aa
   MGG_09917,  M.oryzae
MGG_09917
    XP_003710015.1
906 aa
   NCU09118,  N.crassa
NCU09118
    XP_958033.2
874 aa
   TOP1BETA,  A.thaliana
TOP1BETA
    NP_200342.1
917 aa
   TOP1ALPHA,  A.thaliana
TOP1ALPHA
    NP_200341.1
916 aa
   Os08g0154600,  O.sativa
Os08g0154600
    NP_001061015.1
916 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
DNA topoisomerase I, camptothecin-resistant.



Publications
Articles associated with genes and sequences of this homology group.

Two distinct mechanisms of Topoisomerase 1-dependent mutagenesis in yeast.
Cho JE, et al. DNA Repair (Amst) 12, 205-11 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Hanta_nucleocap (pfam00846)
  Hantavirus nucleocapsid protein.
Topo_C_assoc (pfam14370)
  C-terminal topoisomerase domain.
TOPEUc (smart00435)
  DNA Topoisomerase I (eukaryota).
Topo_C_assoc (pfam14370)
  C-terminal topoisomerase domain.
DNA_BRE_C (cl00213)
  DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site ...
Topoisomer_IB_N (cl02774)
  Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Top1 includes H.sapiens TOP1 and R.norvegicus Top1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (22 transcripts, 9 species)
Mammalia - mammals (20 transcripts, 11 species)
Amphibia - amphibians (6 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 10 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (43 transcripts, 30 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (8 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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