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HomoloGene:9281. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ADAR,  H.sapiens
adenosine deaminase, RNA-specific
    NP_001102.2
1226 aa
   ADAR,  P.troglodytes
adenosine deaminase, RNA-specific
    XP_513841.3
931 aa
   ADAR,  M.mulatta
adenosine deaminase, RNA-specific
    XP_002801843.1
1225 aa
   ADAR,  C.lupus
adenosine deaminase, RNA-specific
    XP_005622842.1
1144 aa
   ADAR,  B.taurus
adenosine deaminase, RNA-specific
    XP_005203862.1
1130 aa
   Adar,  M.musculus
adenosine deaminase, RNA-specific
    NP_062629.3
1152 aa
   Adar,  R.norvegicus
adenosine deaminase, RNA-specific
    NP_112268.1
1175 aa
   ADAR,  G.gallus
adenosine deaminase, RNA-specific
    XP_004948316.1
1153 aa
   adar,  X.tropicalis
adenosine deaminase, RNA-specific
    XP_002943575.2
1199 aa
   adar,  D.rerio
adenosine deaminase, RNA-specific
    NP_571671.1
1382 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dyschromatosis symmetrica hereditaria.



Publications
Articles associated with genes and sequences of this homology group.

ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.
Jiang Q, et al. Proc Natl Acad Sci U S A 110, 1041-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
z-alpha (pfam02295)
  Adenosine deaminase z-alpha domain.
z-alpha (cl02659)
  Adenosine deaminase z-alpha domain.
DSRM (cl00054)
  Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
z-alpha (cl02659)
  Adenosine deaminase z-alpha domain.
A_deamin (cl02661)
  Adenosine-deaminase (editase) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Adar includes H.sapiens ADAR and R.norvegicus Adar.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 12 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

 

 

 

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