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HomoloGene:2271. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SFTPC,  H.sapiens
surfactant protein C
    NP_001165881.1
197 aa
   SFTPC,  P.troglodytes
surfactant protein C
    XP_519645.2
197 aa
   SFTPC,  M.mulatta
surfactant protein C
    NP_001036224.1
191 aa
   SFTPC,  C.lupus
surfactant protein C
    XP_534578.4
200 aa
   SFTPC,  B.taurus
surfactant protein C
    NP_776887.1
190 aa
   Sftpc,  M.musculus
surfactant associated protein C
    NP_035489.2
193 aa
   Sftpc,  R.norvegicus
surfactant protein C
    NP_059038.1
194 aa
   sftpc,  X.tropicalis
surfactant, pulmonary-associated protein C
    NP_001122132.2
176 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pulmonary fibrosis, idiopathic, familial.
Surfactant protein C deficiency.
Pulmonary alveolar proteinosis.
Surfactant metabolism dysfunction, pulmonary, 2.



Publications
Articles associated with genes and sequences of this homology group.

Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient mice.
Glasser SW, et al. Am J Respir Cell Mol Biol 49, 845-54 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SP_C-Propep (pfam08999)
  Surfactant protein C, N terminal propeptide.
SF_P (smart00019)
  Pulmonary surfactant proteins.
BRICHOS (pfam04089)
  BRICHOS domain.
BRICHOS (cl04394)
  BRICHOS domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sftpc includes H.sapiens SFTPC and R.norvegicus Sftpc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)

 

 

 

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