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HomoloGene:1764. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EPCAM,  H.sapiens
epithelial cell adhesion molecule
    NP_002345.2
314 aa
   EPCAM,  P.troglodytes
epithelial cell adhesion molecule
    XP_515458.2
416 aa
   EPCAM,  M.mulatta
epithelial cell adhesion molecule
    NP_001035118.1
314 aa
   EPCAM,  C.lupus
epithelial cell adhesion molecule
    XP_005626295.1
548 aa
   EPCAM,  B.taurus
epithelial cell adhesion molecule
    NP_001030367.1
314 aa
   Epcam,  M.musculus
epithelial cell adhesion molecule
    NP_032558.2
315 aa
   Epcam,  R.norvegicus
epithelial cell adhesion molecule
    NP_612550.1
315 aa
   EPCAM,  G.gallus
epithelial cell adhesion molecule
    NP_001012582.1
306 aa
   epcam,  X.tropicalis
epithelial cell adhesion molecule
    NP_001011149.1
312 aa
   epcam,  D.rerio
epithelial cell adhesion molecule
    NP_001017593.1
303 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diarrhea 5, with tufting enteropathy, congenital.
Colorectal cancer, hereditary nonpolyposis, type I.



Publications
Articles associated with genes and sequences of this homology group.

Absence of cell-surface EpCAM in congenital tufting enteropathy.
Schnell U, et al. Hum Mol Genet 22, 2566-71 (2013).
[A novel genetic disorder of Lynch syndrome - EPCAM gene deletion].
Tomita N, et al. Gan To Kagaku Ryoho 40, 143-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TY (cl00150)
  Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Epcam includes H.sapiens EPCAM and R.norvegicus Epcam.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

 

 

 

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