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HomoloGene:28546. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RBBP8,  H.sapiens
retinoblastoma binding protein 8
    NP_002885.1
897 aa
   RBBP8,  P.troglodytes
retinoblastoma binding protein 8
    XP_001153774.1
895 aa
   RBBP8,  M.mulatta
retinoblastoma binding protein 8
    XP_001093018.2
878 aa
   RBBP8,  C.lupus
retinoblastoma binding protein 8
    XP_005623065.1
900 aa
   RBBP8,  B.taurus
retinoblastoma binding protein 8
    NP_001095436.1
757 aa
   Rbbp8,  M.musculus
retinoblastoma binding protein 8
    NP_001074692.1
893 aa
   Rbbp8,  R.norvegicus
retinoblastoma binding protein 8
    NP_001127889.1
893 aa
   RBBP8,  G.gallus
retinoblastoma binding protein 8
    XP_419158.1
912 aa
   rbbp8,  X.tropicalis
retinoblastoma binding protein 8
    XP_004915272.1
856 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pancreatic carcinoma, somatic.



Publications
Articles associated with genes and sequences of this homology group.

Human CtIP promotes DNA end resection.
Sartori AA, et al. Nature 450, 509-14 (2007).
CtIP, a candidate tumor susceptibility gene is a team player with luminaries.
Chinnadurai G. Biochim Biophys Acta 1765, 67-73 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CtIP_N (pfam10482)
  Tumour-suppressor protein CtIP N-terminal domain.
SAE2 (pfam08573)
  DNA repair protein endonuclease SAE2/CtIP C-terminus.
SAE2 (pfam08573)
  DNA repair protein endonuclease SAE2/CtIP C-terminus.
CtIP_N (pfam10482)
  tumor-suppressor protein CtIP N-terminal domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rbbp8 includes H.sapiens RBBP8 and R.norvegicus Rbbp8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (6 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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