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HomoloGene:47900. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

APOA1,  H.sapiens
apolipoprotein A-I
NP_000030.1
267 aa
APOA1,  P.troglodytes
apolipoprotein A-I
XP_001153383.1
267 aa
APOA1,  M.mulatta
apolipoprotein A-I
XP_001090774.1
267 aa
APOA1,  C.lupus
apolipoprotein A-I
XP_536564.2
266 aa
APOA1,  B.taurus
apolipoprotein A-I
NP_776667.2
265 aa
Apoa1,  M.musculus
apolipoprotein A-I
NP_033822.2
264 aa
Apoa1,  R.norvegicus
apolipoprotein A-I
NP_036870.1
259 aa
APOA1,  G.gallus
apolipoprotein A-I
NP_990856.1
264 aa
apoa1,  X.tropicalis
apolipoprotein A-I
NP_001005127.1
261 aa
apoa1a,  D.rerio
apolipoprotein A-Ia
NP_571203.1
262 aa
apoa1b,  D.rerio
apolipoprotein A-Ib
NP_001093614.2
257 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Amyloidosis, 3 or more types.
ApoA-I and apoC-III deficiency, combined.
Corneal clouding, autosomal recessive.
Hypertriglyceridemia, one form.
Hypoalphalipoproteinemia.



Publications
Articles associated with genes and sequences of this homology group.

Apolipoprotein A-I protection against atherosclerosis is dependent on genetic background.
Sontag TJ, et al. Arterioscler Thromb Vasc Biol 34, 262-9 (2014).
The conformation of lipid-free human apolipoprotein A-I in solution.
Pollard RD, et al. Biochemistry 52, 9470-81 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Apolipoprotein (pfam01442)
  Apolipoprotein A1/A4/E domain.
Apolipoprotein (pfam01442)
  Apolipoprotein A1/A4/E domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Apoa1 includes H.sapiens APOA1 and R.norvegicus Apoa1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Aves - birds (4 transcripts, 3 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)

 

 

 

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