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HomoloGene:4452. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   YAP1,  H.sapiens
Yes-associated protein 1
488 aa
   YAP1,  P.troglodytes
Yes-associated protein 1
488 aa
   LOC704382,  M.mulatta
65 kDa Yes-associated protein-like
488 aa
   YAP1,  C.lupus
Yes-associated protein 1
465 aa
   YAP1,  B.taurus
Yes-associated protein 1
328 aa
   Yap1,  M.musculus
yes-associated protein 1
472 aa
   YAP1,  G.gallus
Yes-associated protein 1
448 aa
   yap1,  X.tropicalis
Yes-associated protein 1
456 aa
   yap1,  D.rerio
Yes-associated protein 1
442 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

The role and clinical significance of YES-associated protein 1 in human osteosarcoma.
Zhang YH, et al. Int J Immunopathol Pharmacol 26, 157-67 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Yap1 includes H.sapiens YAP1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 9 species)
Actinopterygii - bony fishes (7 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)

Insecta - insects (3 transcripts, 3 species)

Anthozoa - anthozoans (1 transcript, 1 species)




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