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HomoloGene:56580. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GYS2,  H.sapiens
glycogen synthase 2 (liver)
    NP_068776.2
703 aa
   GYS2,  P.troglodytes
glycogen synthase 2 (liver)
    XP_520790.2
703 aa
   GYS2,  M.mulatta
glycogen synthase 2 (liver)
    XP_001098578.1
703 aa
   GYS2,  C.lupus
glycogen synthase 2 (liver)
    XP_534869.2
703 aa
   GYS2,  B.taurus
glycogen synthase 2 (liver)
    NP_001179834.1
702 aa
   Gys2,  M.musculus
glycogen synthase 2
    NP_663547.2
704 aa
   Gys2,  R.norvegicus
glycogen synthase 2
    NP_037221.1
703 aa
   GYS2,  G.gallus
glycogen synthase 2 (liver)
    XP_004938048.1
704 aa
   gys2,  D.rerio
glycogen synthase 2
    NP_001018199.1
701 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Glycogen storage disease, type 0.



Publications
Articles associated with genes and sequences of this homology group.

Mutational analysis of the GYS2 gene in patients diagnosed with ketotic hypoglycaemia.
Nessa A, et al. J Pediatr Endocrinol Metab 25, 963-7 (2012).
Glucose induces the translocation of glycogen synthase to the cell cortex in rat hepatocytes.
Fernández-Novell JM, et al. Biochem J 321 ( Pt 1), 227-31 (1997).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Glycogen_syn (pfam05693)
  Glycogen synthase.
Glycogen_syn (pfam05693)
  Glycogen synthase.
Glycosyltransferase_GTB_type (cl10013)
  Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gys2 includes H.sapiens GYS2 and R.norvegicus Gys2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (6 transcripts, 3 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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