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HomoloGene:1789. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MC1R,  H.sapiens
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
    NP_002377.4
317 aa
   MC1R,  P.troglodytes
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
    NP_001009152.1
317 aa
   MC1R,  C.lupus
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
    NP_001014304.1
317 aa
   MC1R,  B.taurus
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
    NP_776533.1
317 aa
   Mc1r,  M.musculus
melanocortin 1 receptor
    NP_032585.2
315 aa
   Mc1r,  R.norvegicus
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
    XP_006255857.1
317 aa
   MC1R,  G.gallus
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
    NP_001026633.1
314 aa
   mc1r,  X.tropicalis
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
    XP_002937630.2
334 aa
   mc1r,  D.rerio
melanocortin 1 receptor
    NP_851301.1
323 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Analgesia from kappa-opioid receptor agonist, female-specific.
Blond/light brown hair and/or fair skin.
Melanoma, susceptiblity to.
Red hair/fair skin.
UV-induced skin damage, susceptibility to.
Oculocutaneous albinism, type II, modifier of.



Publications
Articles associated with genes and sequences of this homology group.

[Association study of MC1R gene polymorphisms with freckles in Chinese Han population from Chengdu].
Cao L, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30, 352-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mc1r includes H.sapiens MC1R.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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