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HomoloGene:7899. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   PPARG,  H.sapiens
peroxisome proliferator-activated receptor gamma
505 aa
   PPARG,  P.troglodytes
peroxisome proliferator-activated receptor gamma
505 aa
   PPARG,  M.mulatta
peroxisome proliferator-activated receptor gamma
505 aa
   PPARG,  C.lupus
peroxisome proliferator-activated receptor gamma
505 aa
   PPARG,  B.taurus
peroxisome proliferator-activated receptor gamma
505 aa
   Pparg,  M.musculus
peroxisome proliferator activated receptor gamma
505 aa
   Pparg,  R.norvegicus
peroxisome proliferator-activated receptor gamma
505 aa
   PPARG,  G.gallus
peroxisome proliferator-activated receptor gamma
475 aa
   pparg,  D.rerio
peroxisome proliferator activated receptor gamma
527 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Glioblastoma, susceptibility to.
Lipodystrophy, familial partial.
Obesity, resistance to.
Obesity, severe.
Diabetes mellitus, insulin-resistant, with acanthosis nigricans and hypertension.
Insulin resistance, severe, digenic.
Abdominal body fat distribution, modifier of.

Articles associated with genes and sequences of this homology group.

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ.
Wang F, et al. Proc Natl Acad Sci U S A 110, 18656-61 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PPARgamma_N (pfam12577)
  PPAR gamma N-terminal region.
PPARgamma_N (pfam12577)
  PPAR gamma N-terminal region.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pparg includes H.sapiens PPARG and R.norvegicus Pparg.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 14 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)




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