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HomoloGene:38148. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NCK1,  H.sapiens
NCK adaptor protein 1
    NP_006144.1
377 aa
   NCK1,  P.troglodytes
NCK adaptor protein 1
    NP_001233509.1
377 aa
   NCK1,  M.mulatta
NCK adaptor protein 1
    XP_002803036.1
377 aa
   NCK1,  C.lupus
NCK adaptor protein 1
    XP_005634527.1
377 aa
   NCK1,  B.taurus
NCK adaptor protein 1
    NP_001069540.1
377 aa
   Nck1,  M.musculus
non-catalytic region of tyrosine kinase adaptor protein 1
    NP_035008.2
377 aa
   Nck1,  R.norvegicus
NCK adaptor protein 1
    NP_001100321.1
377 aa
   nck1,  X.tropicalis
nck1 protein
    NP_001008101.1
377 aa
   nck1b,  D.rerio
NCK adaptor protein 1b
    XP_005162580.1
381 aa
   dock,  D.melanogaster
dreadlocks
    NP_001259845.1
548 aa
   AgaP_AGAP010135,  A.gambiae
AgaP_AGAP010135
    XP_319290.3
391 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Nck1 deficiency accelerates unloading-induced bone loss.
Aryal AC, et al. J Cell Physiol 228, 1397-403 (2013).
Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function.
Yiemwattana I, et al. Clin Exp Immunol 167, 99-107 (2012).
Domain requirements for the Dock adapter protein in growth- cone signaling.
Rao Y & Zipursky SL. Proc Natl Acad Sci U S A 95, 2077-82 (1998).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nck1 includes H.sapiens NCK1 and R.norvegicus Nck1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 15 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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