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HomoloGene:593. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CHRNA7,  H.sapiens
cholinergic receptor, nicotinic, alpha 7 (neuronal)
    NP_000737.1
502 aa
   CHRNA7,  P.troglodytes
cholinergic receptor, nicotinic, alpha 7 (neuronal)
    XP_001164138.1
502 aa
   CHRNA7,  M.mulatta
cholinergic receptor, nicotinic, alpha 7 (neuronal)
    NP_001028055.1
502 aa
   CHRNA7,  C.lupus
cholinergic receptor, nicotinic, alpha 7 (neuronal)
    XP_545813.4
499 aa
   CHRNA7,  B.taurus
cholinergic receptor, nicotinic, alpha 7
    NP_776940.1
499 aa
   Chrna7,  M.musculus
cholinergic receptor, nicotinic, alpha polypeptide 7
    NP_031416.3
502 aa
   Chrna7,  R.norvegicus
cholinergic receptor, nicotinic, alpha 7 (neuronal)
    NP_036964.3
502 aa
   CHRNA7,  G.gallus
cholinergic receptor, nicotinic, alpha 7 (neuronal)
    NP_989512.2
502 aa
   LOC100493611,  X.tropicalis
neuronal acetylcholine receptor subunit alpha-7-like
    XP_002937717.2
504 aa
   chrna7,  D.rerio
cholinergic receptor, nicotinic, alpha polypeptide 7
    NP_957513.1
509 aa
   nAcRalpha-34E,  D.melanogaster
nicotinic Acetylcholine Receptor alpha 34E
    NP_001246027.1
808 aa
   AgaP_AGAP008588,  A.gambiae
AgaP_AGAP008588
    XP_314691.2
533 aa
   acr-16,  C.elegans
acr-16
    NP_505207.1
498 aa
   acr-25,  C.elegans
acr-25
    NP_001023570.2
544 aa
   acr-11,  C.elegans
acr-11
    NP_491906.1
461 aa
   acr-9,  C.elegans
acr-9
    NP_510285.2
534 aa
   acr-14,  C.elegans
acr-14
    NP_495716.1
500 aa
   acr-10,  C.elegans
acr-10
    NP_508692.2
571 aa
   acr-7,  C.elegans
acr-7
    NP_495647.1
538 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Schizophrenia, neurophysiologic defect in.



Publications
Articles associated with genes and sequences of this homology group.

Stoichiometry for activation of neuronal α7 nicotinic receptors.
Andersen N, et al. Proc Natl Acad Sci U S A 110, 20819-24 (2013).
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.
Yang Y, et al. Proc Natl Acad Sci U S A 110, 12078-83 (2013).
Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.
Azzopardi E, et al. Genes Brain Behav 12, 414-23 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Neur_chan_memb (pfam02932)
  Neurotransmitter-gated ion-channel transmembrane region.
Neur_chan_LBD (pfam02931)
  Neurotransmitter-gated ion-channel ligand binding domain.
Neur_chan_memb (pfam02932)
  Neurotransmitter-gated ion-channel transmembrane region.
Neur_chan_LBD (pfam02931)
  Neurotransmitter-gated ion-channel ligand binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chrna7 includes H.sapiens CHRNA7 and R.norvegicus Chrna7.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (6 transcripts, 4 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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