Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:3421. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   BAP1,  H.sapiens
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    NP_004647.1
729 aa
   BAP1,  P.troglodytes
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    XP_001171970.1
729 aa
   BAP1,  M.mulatta
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    XP_001089173.1
729 aa
   BAP1,  C.lupus
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    XP_541853.2
729 aa
   BAP1,  B.taurus
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    NP_001096019.1
711 aa
   Bap1,  M.musculus
Brca1 associated protein 1
    NP_081364.1
728 aa
   Bap1,  R.norvegicus
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    NP_001100762.1
740 aa
   BAP1,  G.gallus
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    NP_001025761.1
700 aa
   bap1,  X.tropicalis
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    NP_001008206.1
685 aa
   bap1,  D.rerio
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
    NP_001157309.1
755 aa
   calypso,  D.melanogaster
calypso
    NP_788374.1
471 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair.
Yu H, et al. Proc Natl Acad Sci U S A 111, 285-90 (2014).
BAP1 is phosphorylated at serine 592 in S-phase following DNA damage.
Eletr ZM, et al. FEBS Lett 587, 3906-11 (2013).
BAP1 germline mutation in two first grade family members with uveal melanoma.
Maerker DA, et al. Br J Ophthalmol 98, 224-7 (2014).
Germline BAP1 mutations predispose to renal cell carcinomas.
Popova T, et al. Am J Hum Genet 92, 974-80 (2013).
Hereditary uveal melanoma: a report of a germline mutation in BAP1.
Höiom V, et al. Genes Chromosomes Cancer 52, 378-84 (2013).
Tumours associated with BAP1 mutations.
Murali R, et al. Pathology 45, 116-26 (2013).
Prevalence of germline BAP1 mutation in a population-based sample of uveal melanoma cases.
Aoude LG, et al. Pigment Cell Melanoma Res 26, 278-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Peptidase_C12 (cl08306)
  Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bap1 includes H.sapiens BAP1 and R.norvegicus Bap1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 11 species)
Actinopterygii - bony fishes (11 transcripts, 7 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

Write to the Help Desk