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HomoloGene:68524. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HSPA8,  H.sapiens
heat shock 70kDa protein 8
NP_006588.1
646 aa
HSPA8,  P.troglodytes
heat shock 70kDa protein 8
XP_003313441.2
646 aa
HSPA8,  M.mulatta
heat shock 70kDa protein 8
XP_002799868.1
646 aa
HSPA8,  C.lupus
heat shock 70kDa protein 8
XP_005619707.1
646 aa
HSPA8,  B.taurus
heat shock 70kDa protein 8
NP_776770.2
650 aa
Hspa8,  M.musculus
heat shock protein 8
NP_112442.2
646 aa
Hspa8,  R.norvegicus
heat shock 70kDa protein 8
NP_077327.1
646 aa
HSPA8,  G.gallus
heat shock 70kDa protein 8
NP_990334.1
646 aa
hspa8,  X.tropicalis
heat shock 70kDa protein 8
XP_004916187.1
646 aa
hspa8,  D.rerio
heat shock protein 8
NP_001103873.1
649 aa
Hsc70-1,  D.melanogaster
Heat shock protein cognate 1
NP_524063.1
641 aa
AgaP_AGAP004944,  A.gambiae
AgaP_AGAP004944
XP_315042.3
647 aa
hsp-1,  C.elegans
hsp-1
NP_503068.1
640 aa
AT3G09440,  A.thaliana
AT3G09440
NP_001189847.1
649 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
First recognized by sequence similarity to Hsp70. Transcription is developmentally regulated, but is temperature independent.



Publications
Articles associated with genes and sequences of this homology group.

Redox regulation of cellular stress response in multiple sclerosis.
Pennisi G, et al. Biochem Pharmacol 82, 1490-9 (2011).
Diagnostic protein marker patterns in squamous cervical cancer.
Lomnytska MI, et al. Proteomics Clin Appl 4, 17-31 (2010).
Arginine 469 is a pivotal residue for the Hsc70-GlcNAc-binding property.
Guinez C, et al. Biochem Biophys Res Commun 400, 537-42 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTZ00009 (PTZ00009)
  heat shock 70 kDa protein; Provisional.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hspa8 includes H.sapiens HSPA8 and R.norvegicus Hspa8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (83 transcripts, 18 species)
Actinopterygii - bony fishes (81 transcripts, 12 species)
Ascidiacea - tunicates (18 transcripts, 3 species)
Amphibia - amphibians (17 transcripts, 2 species)
Cephalochordata - lancelets (10 transcripts, 1 species)
Aves - birds (3 transcripts, 3 species)
Hyperoartia - vertebrates (3 transcripts, 1 species)

Arthropoda
Insecta - insects (47 transcripts, 12 species)
Arachnida - arachnids (12 transcripts, 2 species)
Maxillopoda - crustaceans (5 transcripts, 1 species)
Branchiopoda - crustaceans (4 transcripts, 1 species)
Malacostraca - crustaceans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (14 transcripts, 2 species)
Turbellaria - flatworms (9 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (18 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (10 transcripts, 2 species)
Anthozoa - anthozoans (7 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (7 transcripts, 1 species)
Hirudinida - segmented worms (3 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (8 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Streptophyta
Eudicotyledons - eudicots (89 transcripts, 23 species)
Liliopsida - monocots (24 transcripts, 6 species)
Coniferopsida - conifers (17 transcripts, 3 species)

Ascomycota
Sordariomycetes - ascomycetes (27 transcripts, 2 species)
Pezizomycetes - ascomycetes (2 transcripts, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (14 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (4 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (8 transcripts, 1 species)
Pythiales - oomycetes (3 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (5 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (5 transcripts, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

 

 

 

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