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HomoloGene:4072. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   LMO2,  H.sapiens
LIM domain only 2 (rhombotin-like 1)
227 aa
   LMO2,  P.troglodytes
LIM domain only 2 (rhombotin-like 1)
226 aa
   LMO2,  M.mulatta
LIM domain only 2 (rhombotin-like 1)
222 aa
   LOC609006,  C.lupus
uncharacterized LOC609006
642 aa
   Lmo2,  M.musculus
LIM domain only 2
220 aa
   Lmo2,  R.norvegicus
LIM domain only 2
220 aa
   LMO2,  G.gallus
LIM domain only 2 (rhombotin-like 1)
158 aa
   lmo2,  X.tropicalis
LIM domain only 2 (rhombotin-like 1)
158 aa
   lmo2,  D.rerio
LIM domain only 2 (rhombotin-like 1)
159 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Leukemia, acute T-cell.

Articles associated with genes and sequences of this homology group.

Building multifunctionality into a complex containing master regulators of hematopoiesis.
Fujiwara T, et al. Proc Natl Acad Sci U S A 107, 20429-34 (2010).
Purification, crystallization and preliminary X-ray analysis of a fusion of the LIM domains of LMO2 and the LID domain of Ldb1.
El Omari K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 1466-9 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LIM (cl02475)
  LIM is a small protein-protein interaction domain, containing two zinc fingers.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lmo2 includes H.sapiens LMO2 and R.norvegicus Lmo2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 10 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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