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HomoloGene:9280. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DMRT1,  H.sapiens
doublesex and mab-3 related transcription factor 1
    NP_068770.2
373 aa
   DMRT1,  P.troglodytes
doublesex and mab-3 related transcription factor 1
    XP_003312067.1
371 aa
   LOC100425397,  M.mulatta
doublesex- and mab-3-related transcription factor 1-like
    XP_002800204.1
215 aa
   DMRT1,  C.lupus
doublesex and mab-3 related transcription factor 1
    XP_851495.1
378 aa
   DMRT1,  B.taurus
doublesex and mab-3 related transcription factor 1
    NP_001071528.1
276 aa
   Dmrt1,  M.musculus
doublesex and mab-3 related transcription factor 1
    NP_056641.2
374 aa
   Dmrt1,  R.norvegicus
doublesex and mab-3 related transcription factor 1
    NP_446158.1
374 aa
   dmrt1,  X.tropicalis
doublesex and mab-3 related transcription factor 1
    XP_002935648.2
336 aa
   dmrt1,  D.rerio
doublesex and mab-3 related transcription factor 1
    NP_991191.1
267 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
XY sex reversal.



Publications
Articles associated with genes and sequences of this homology group.

Regulation of pluripotency in male germline stem cells by Dmrt1.
Takashima S, et al. Genes Dev 27, 1949-58 (2013).
An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci.
Bradley KM, et al. G3 (Bethesda) 1, 3-9 (2011).
Intestinal iron absorption: regulation by dietary & systemic factors.
Sharp PA. Int J Vitam Nutr Res 80, 231-42 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DM (pfam00751)
  DM DNA binding domain.
Dmrt1 (pfam12374)
  Double-sex mab3 related transcription factor 1.
Dmrt1 (pfam12374)
  Double-sex mab3 related transcription factor 1.
DM (cl02557)
  DM DNA binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dmrt1 includes H.sapiens DMRT1 and R.norvegicus Dmrt1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (7 transcripts, 5 species)
Mammalia - mammals (6 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

 

 

 

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