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HomoloGene:3151. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MED17,  H.sapiens
mediator complex subunit 17
    NP_004259.3
651 aa
   MED17,  P.troglodytes
mediator complex subunit 17
    XP_508698.3
651 aa
   MED17,  M.mulatta
mediator complex subunit 17
    XP_001088365.1
651 aa
   MED17,  C.lupus
mediator complex subunit 17
    XP_533975.3
651 aa
   MED17,  B.taurus
mediator complex subunit 17
    NP_001029902.2
651 aa
   Med17,  M.musculus
mediator complex subunit 17
    NP_659182.1
649 aa
   Med17,  R.norvegicus
mediator complex subunit 17
    NP_001100271.1
649 aa
   MED17,  G.gallus
mediator complex subunit 17
    NP_001006280.1
643 aa
   med17,  X.tropicalis
mediator complex subunit 17
    NP_001016974.1
639 aa
   med17,  D.rerio
mediator complex subunit 17
    NP_001071042.1
643 aa
   MED17,  D.melanogaster
Mediator complex subunit 17
    NP_650686.1
642 aa
   MED17_ANOGA,  A.gambiae
MED17_ANOGA
    XP_319901.2
645 aa
   mdt-17,  C.elegans
mdt-17
    NP_001256910.1
667 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Microcephaly, postnatal progressive, with seizures and brain atrophy.



Publications
Articles associated with genes and sequences of this homology group.

Mediator and post-recruitment regulation of RNA polymerase II.
Knuesel MT & Taatjes DJ. Transcription 2, 28-31 (2011).
The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme.
Chiba N & Parvin JD. Cancer Res 62, 4222-8 (2002).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Med17 (pfam10156)
  Subunit 17 of Mediator complex.
Med17 (pfam10156)
  Subunit 17 of Mediator complex.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Med17 includes H.sapiens MED17 and R.norvegicus Med17.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (16 transcripts, 10 species)
Mammalia - mammals (13 transcripts, 12 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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