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HomoloGene:37906. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

G6PD,  H.sapiens
glucose-6-phosphate dehydrogenase
NP_000393.4
545 aa
G6PD,  M.mulatta
glucose-6-phosphate dehydrogenase
XP_001095382.1
545 aa
G6PD,  C.lupus
glucose-6-phosphate dehydrogenase
XP_538209.2
545 aa
G6PD,  B.taurus
glucose-6-phosphate dehydrogenase
NP_001231064.1
545 aa
G6pdx,  M.musculus
glucose-6-phosphate dehydrogenase X-linked
NP_032088.1
515 aa
G6pd,  R.norvegicus
glucose-6-phosphate dehydrogenase
NP_058702.1
515 aa
g6pd,  X.tropicalis
glucose-6-phosphate dehydrogenase
NP_001017312.1
500 aa
g6pd,  D.rerio
glucose-6-phosphate dehydrogenase
XP_699168.3
523 aa
Zw,  D.melanogaster
Zwischenferment
NP_523411.1
524 aa
AgaP_AGAP010739,  A.gambiae
AgaP_AGAP010739
XP_559252.3
546 aa
AgaP_AGAP012678,  A.gambiae
AgaP_AGAP012678
XP_307095.4
474 aa
gspd-1,  C.elegans
gspd-1
NP_502129.1
522 aa
ZWF1,  S.cerevisiae
ZWF1
NP_014158.1
505 aa
KLLA0D19855g,  K.lactis
KLLA0D19855g
XP_453944.1
497 aa
AGOS_ABL206C,  E.gossypii
AGOS_ABL206C
NP_982741.1
512 aa
zwf1,  S.pombe
zwf1
NP_593344.2
500 aa
MGG_09926,  M.oryzae
MGG_09926
XP_003710026.1
507 aa
NCU09111,  N.crassa
NCU09111
XP_958320.2
499 aa
G6PD5,  A.thaliana
G6PD5
NP_001030780.1
516 aa
G6PD6,  A.thaliana
G6PD6
NP_198892.1
515 aa
Os02g0600400,  O.sativa
Os02g0600400
NP_001047345.1
517 aa
Os04g0485300,  O.sativa
Os04g0485300
NP_001053132.1
505 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Structural gene for glucose 6-phosphate dehydrogenase (Zwischenferment of Warburg) (G6PD), the first enzyme in the oxidative part of the pentose phosphate shunt. Electrophoretic variants ZwA and ZwB have been described in D.melanogaster (Young, Porter and Childs, 1964; Young, 1966). The G6PD produced by ZwA shows faster migration in starch gel (Young et al., 1964) by ZwB. A ZwA/ZwB female shows fast- and slow-migrating bands but no hybrid band of intermediate mobility (Young et al., 1964; Steele, Young and Childs, 1968; Hori and Tanda, 1980). (See FlyBase for complete description.)

H.sapiens
Favism.
G6PD deficiency.
Hemolytic anemia due to G6PD deficiency.



Publications
Articles associated with genes and sequences of this homology group.

A model of glucose-6-phosphate dehydrogenase deficiency in the zebrafish.
Patrinostro X, et al. Exp Hematol 41, 697-710.e2 (2013).
3'-UTR variations and G6PD deficiency.
Amini F & Ismail E. J Hum Genet 58, 189-94 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
G6PD_N (pfam00479)
  Glucose-6-phosphate dehydrogenase, NAD binding domain.
G6PD_C (pfam02781)
  Glucose-6-phosphate dehydrogenase, C-terminal domain.
G6PD_N (pfam00479)
  Glucose-6-phosphate dehydrogenase, NAD binding domain.
G6PD_C (pfam02781)
  Glucose-6-phosphate dehydrogenase, C-terminal domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus G6pdx includes H.sapiens G6PD and R.norvegicus G6pd.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (68 transcripts, 35 species)
Liliopsida - monocots (20 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Bryopsida - mosses (3 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chordata
Actinopterygii - bony fishes (27 transcripts, 12 species)
Mammalia - mammals (14 transcripts, 13 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (6 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (3 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (3 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (3 transcripts, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

 

 

 

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