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HomoloGene:3879. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GRK5,  H.sapiens
G protein-coupled receptor kinase 5
    NP_005299.1
590 aa
   GRK5,  P.troglodytes
G protein-coupled receptor kinase 5
    XP_003312835.1
584 aa
   LOC100427251,  M.mulatta
G protein-coupled receptor kinase 5-like
    XP_002805891.1
664 aa
   GRK5,  C.lupus
G protein-coupled receptor kinase 5
    XP_544045.3
590 aa
   GRK5,  B.taurus
G protein-coupled receptor kinase 5
    NP_776756.1
590 aa
   Grk5,  M.musculus
G protein-coupled receptor kinase 5
    NP_061357.3
590 aa
   Grk5,  R.norvegicus
G protein-coupled receptor kinase 5
    NP_110456.1
590 aa
   GRK5,  G.gallus
G protein-coupled receptor kinase 5
    XP_421789.2
590 aa
   LOC100497344,  X.tropicalis
G protein-coupled receptor kinase 5-like
    XP_002940394.1
590 aa
   Gprk2,  D.melanogaster
G protein-coupled receptor kinase 2
    NP_476867.1
714 aa
   AgaP_AGAP004117,  A.gambiae
AgaP_AGAP004117
    XP_312995.5
697 aa
   grk-1,  C.elegans
grk-1
    NP_509676.1
642 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

GRK5 ablation contributes to insulin resistance.
Wang L, et al. Biochem Biophys Res Commun 429, 99-104 (2012).
GRK5 deficiency decreases diet-induced obesity and adipogenesis.
Wang F, et al. Biochem Biophys Res Commun 421, 312-7 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pkinase_C (cl11395)
  Protein kinase C terminal domain.
RGS (cl02565)
  Regulator of G protein signaling (RGS) domain superfamily.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Pkinase_C (cl11395)
  Protein kinase C terminal domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Grk5 includes H.sapiens GRK5 and R.norvegicus Grk5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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