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HomoloGene:85014. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KCNQ1,  H.sapiens
potassium voltage-gated channel, KQT-like subfamily, member 1
    NP_000209.2
676 aa
   KCNQ1,  P.troglodytes
potassium voltage-gated channel, KQT-like subfamily, member 1
    XP_003312922.2
1195 aa
   KCNQ1,  C.lupus
potassium voltage-gated channel, KQT-like subfamily, member 1
    XP_005631798.1
679 aa
   KCNQ1,  B.taurus
potassium voltage-gated channel, KQT-like subfamily, member 1
    NP_001192370.1
670 aa
   Kcnq1,  M.musculus
potassium voltage-gated channel, subfamily Q, member 1
    NP_032460.2
668 aa
   Kcnq1,  R.norvegicus
potassium voltage-gated channel, KQT-like subfamily, member 1
    NP_114462.1
669 aa
   KCNQ1,  G.gallus
potassium voltage-gated channel, KQT-like subfamily, member 1
    XP_421022.3
668 aa
   kcnq1,  X.tropicalis
potassium voltage-gated channel, KQT-like subfamily, member 1
    XP_002936545.2
659 aa
   kcnq1,  D.rerio
potassium voltage-gated channel, KQT-like subfamily, member 1
    NP_001116714.1
655 aa
   kqt-3,  C.elegans
kqt-3
    NP_001254404.1
617 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Long QT syndrome-1.
Jervell and Lange-Nielsen syndrome.
Torsades de pointes, drug-associated.
Atrial fibrillation, familial.
Short QT syndrome-2.



Publications
Articles associated with genes and sequences of this homology group.

Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening.
Zaydman MA, et al. Proc Natl Acad Sci U S A 110, 13180-5 (2013).
A KCNQ1 mutation causes a high penetrance for familial atrial fibrillation.
Bartos DC, et al. J Cardiovasc Electrophysiol 24, 562-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
KCNQ_channel (pfam03520)
  KCNQ voltage-gated potassium channel.
Ion_trans (pfam00520)
  Ion transport protein.
KCNQ_channel (pfam03520)
  KCNQ voltage-gated potassium channel.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kcnq1 includes H.sapiens KCNQ1 and R.norvegicus Kcnq1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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