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HomoloGene:17790. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PCSK9,  H.sapiens
proprotein convertase subtilisin/kexin type 9
    NP_777596.2
692 aa
   PCSK9,  P.troglodytes
proprotein convertase subtilisin/kexin type 9
    NP_001104592.1
692 aa
   PCSK9,  M.mulatta
proprotein convertase subtilisin/kexin type 9
    NP_001106130.1
692 aa
   Pcsk9,  M.musculus
proprotein convertase subtilisin/kexin type 9
    NP_705793.1
694 aa
   Pcsk9,  R.norvegicus
proprotein convertase subtilisin/kexin type 9
    NP_954862.2
691 aa
   PCSK9,  G.gallus
proprotein convertase subtilisin/kexin type 9
    XP_003641739.2
815 aa
   pcsk9,  X.tropicalis
proprotein convertase subtilisin/kexin type 9
    XP_002931479.1
676 aa
   pcsk9,  D.rerio
proprotein convertase subtilisin/kexin type 9
    XP_003200725.1
667 aa
   YSP3,  S.cerevisiae
YSP3
    NP_014645.1
478 aa
   psp3,  S.pombe
psp3
    NP_594848.1
451 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypercholesterolemia, familial, 3.



Publications
Articles associated with genes and sequences of this homology group.

The promises of PCSK9 inhibition.
Petrides F, et al. Curr Opin Lipidol 24, 307-12 (2013).
Plasma PCSK9 is a late biomarker of severity in patients with severe trauma injury.
Le Bras M, et al. J Clin Endocrinol Metab 98, E732-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Inhibitor_I9 (pfam05922)
  Peptidase inhibitor I9.
Inhibitor_I9 (pfam05922)
  Peptidase inhibitor I9.
Peptidases_S8_S53 (cl10459)
  Peptidase domain in the S8 and S53 families.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pcsk9 includes H.sapiens PCSK9 and R.norvegicus Pcsk9.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 5 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (5 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (5 transcripts, 1 species)
Sordariomycetes - ascomycetes (2 transcripts, 2 species)

Bacillariophyta
Bacillariophyceae - diatoms (7 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (3 transcripts, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)
Coniferopsida - conifers (1 transcript, 1 species)

 

 

 

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