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HomoloGene:74962. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MAPT,  H.sapiens
microtubule-associated protein tau
    NP_001116538.2
776 aa
   MAPT,  P.troglodytes
microtubule-associated protein tau
    NP_001009068.1
776 aa
   MAPT,  M.mulatta
microtubule-associated protein tau
    XP_002800599.1
776 aa
   MAPT,  C.lupus
microtubule-associated protein tau
    NP_001104271.1
765 aa
   MAPT,  B.taurus
microtubule-associated protein tau
    NP_776531.1
448 aa
   Mapt,  M.musculus
microtubule-associated protein tau
    NP_001033698.1
430 aa
   Mapt,  R.norvegicus
microtubule-associated protein tau
    NP_058908.2
374 aa
   MAPT,  G.gallus
microtubule-associated protein tau
    NP_001186122.1
432 aa
   mapt,  X.tropicalis
microtubule-associated protein tau
    NP_001072465.1
403 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Tauopathy and respiratory failure.
Parkinson disease.
Pick disease.
Supranuclear palsy, progressive atypical.
Dementia, frontotemporal, with or without parkinsonism.
Supranuclear palsy, progressive.



Publications
Articles associated with genes and sequences of this homology group.

Structural determinants of Tau aggregation inhibitor potency.
Schafer KN, et al. J Biol Chem 288, 32599-611 (2013).
Tau pathology and neurodegeneration.
Spillantini MG & Goedert M. Lancet Neurol 12, 609-22 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tubulin-binding (pfam00418)
  Tau and MAP protein, tubulin-binding repeat.
DUF566 (pfam04484)
  Family of unknown function (DUF566).
DUF4540 (pfam15073)
  Domain of unknown function (DUF4540).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mapt includes H.sapiens MAPT and R.norvegicus Mapt.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (13 transcripts, 8 species)
Mammalia - mammals (12 transcripts, 10 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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