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HomoloGene:111783. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PICALM,  H.sapiens
phosphatidylinositol binding clathrin assembly protein
    NP_001193875.1
645 aa
   PICALM,  P.troglodytes
phosphatidylinositol binding clathrin assembly protein
    XP_003952040.1
645 aa
   PICALM,  M.mulatta
phosphatidylinositol binding clathrin assembly protein
    XP_002799775.1
652 aa
   PICALM,  C.lupus
phosphatidylinositol binding clathrin assembly protein
    XP_005633453.1
687 aa
   PICALM,  B.taurus
phosphatidylinositol binding clathrin assembly protein
    NP_001095447.1
660 aa
   Picalm,  M.musculus
phosphatidylinositol binding clathrin assembly protein
    NP_666306.2
660 aa
   Picalm,  R.norvegicus
phosphatidylinositol binding clathrin assembly protein
    NP_446006.1
640 aa
   PICALM,  G.gallus
phosphatidylinositol binding clathrin assembly protein
    XP_423671.4
635 aa
   picalm.2,  X.tropicalis
phosphatidylinositol binding clathrin assembly protein, gene 2
    NP_001164996.1
597 aa
   picalma,  D.rerio
phosphatidylinositol binding clathrin assembly protein a
    NP_957221.1
589 aa
   lap,  D.melanogaster
like-AP180
    NP_001262338.1
704 aa
   AgaP_AGAP010087,  A.gambiae
AgaP_AGAP010087
    XP_319245.3
682 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, acute myeloid.
Leukemia, acute T-cell lymphoblastic.



Publications
Articles associated with genes and sequences of this homology group.

Alzheimer's disease risk genes and the age-at-onset phenotype.
Thambisetty M, et al. Neurobiol Aging 34, 2696.e1-5 (2013).
Association of GWAS top hits with late-onset Alzheimer disease in Korean population.
Chung SJ, et al. Alzheimer Dis Assoc Disord 27, 250-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Amelogenin (smart00818)
  Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth.
COG4223 (COG4223)
  Uncharacterized protein conserved in bacteria [Function unknown].
VHS_ENTH_ANTH (cl02544)
  VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Picalm includes H.sapiens PICALM and R.norvegicus Picalm.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (30 transcripts, 9 species)
Mammalia - mammals (16 transcripts, 13 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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