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HomoloGene:20929. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   EPHA2,  H.sapiens
EPH receptor A2
976 aa
   EPHA2,  P.troglodytes
EPH receptor A2
1199 aa
   EPHA2,  M.mulatta
EPH receptor A2
976 aa
   EPHA2,  C.lupus
EPH receptor A2
975 aa
   EPHA2,  B.taurus
EPH receptor A2
975 aa
   Epha2,  M.musculus
Eph receptor A2
977 aa
   Epha2,  R.norvegicus
Eph receptor A2
977 aa
   EPHA2,  G.gallus
EPH receptor A2
972 aa
   epha2,  X.tropicalis
EPH receptor A2
974 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Cataract, posterior polar, 1.

Articles associated with genes and sequences of this homology group.

Evidence that the EphA2 receptor exacerbates ischemic brain injury.
Thundyil J, et al. PLoS One 8, e53528 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Laminin_EGF (pfam00053)
  Laminin EGF-like (Domains III and V).
GCC2_GCC3 (pfam07699)
  GCC2 and GCC3.
TNFR (cd00185)
  Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
GCC2_GCC3 (pfam07699)
  GCC2 and GCC3.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
EphR_LBD (cl02704)
  Ligand Binding Domain of Ephrin Receptors.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
TM_EphA1 (cl17164)
  Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Epha2 includes H.sapiens EPHA2 and R.norvegicus Epha2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (11 transcripts, 6 species)
Mammalia - mammals (10 transcripts, 9 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)




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