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HomoloGene:193. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LEP,  H.sapiens
leptin
    NP_000221.1
167 aa
   LEP,  P.troglodytes
leptin
    NP_001180601.1
167 aa
   LEP,  M.mulatta
leptin
    NP_001036220.1
167 aa
   LEP,  C.lupus
leptin
    NP_001003070.1
167 aa
   LEP,  B.taurus
leptin
    NP_776353.2
167 aa
   Lep,  M.musculus
leptin
    NP_032519.1
167 aa
   Lep,  R.norvegicus
leptin
    NP_037208.1
167 aa
   LOC100486715,  X.tropicalis
leptin-like
    XP_002931881.2
169 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Obesity, morbid, with hypogonadism.
Obesity, severe, due to leptin deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Leptin promotes lupus T-cell autoimmunity.
Amarilyo G, et al. Clin Immunol 149, 530-3 (2013).
Reporter islets in the eye reveal the plasticity of the endocrine pancreas.
Ilegems E, et al. Proc Natl Acad Sci U S A 110, 20581-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lep includes H.sapiens LEP and R.norvegicus Lep.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 12 species)
Aves - birds (2 transcripts, 2 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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