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HomoloGene:13024. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CARD11,  H.sapiens
caspase recruitment domain family, member 11
    NP_115791.3
1154 aa
   CARD11,  P.troglodytes
caspase recruitment domain family, member 11
    XP_518943.3
1154 aa
   CARD11,  M.mulatta
caspase recruitment domain family, member 11
    XP_001104636.2
1195 aa
   CARD11,  C.lupus
caspase recruitment domain family, member 11
    XP_005621207.1
1154 aa
   CARD11,  B.taurus
caspase recruitment domain family, member 11
    NP_001103266.1
1146 aa
   Card11,  M.musculus
caspase recruitment domain family, member 11
    NP_780571.2
1154 aa
   LOC100363332,  R.norvegicus
caspase recruitment domain family, member 11
    XP_006249045.1
1157 aa
   CARD11,  G.gallus
caspase recruitment domain family, member 11
    NP_001006161.2
1170 aa
   LOC557072,  D.rerio
caspase recruitment domain-containing protein 11-like
    XP_685144.6
1122 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Crystallization and preliminary X-ray crystallographic studies of the CARD domain of human CARMA1.
Park JH & Park HH. Acta Crystallogr Sect F Struct Biol Cryst Commun 69, 435-7 (2013).
Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma.
Montesinos-Rongen M, et al. Acta Neuropathol 120, 529-35 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CARD_CARD11_CARMA1 (cd08808)
  Caspase activation and recruitment domain of CARD11-like proteins.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
NAT_SF (cl00357)
  N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
NK (cl17190)
  Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
NK (cl17190)
  Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Card11 includes H.sapiens CARD11.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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