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HomoloGene:1326. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CAPN2,  H.sapiens
calpain 2, (m/II) large subunit
    NP_001739.2
700 aa
   CAPN2,  P.troglodytes
calpain 2, (m/II) large subunit
    XP_003308813.1
700 aa
   CAPN2,  M.mulatta
calpain 2, (m/II) large subunit
    XP_001098172.1
700 aa
   CAPN2,  C.lupus
calpain 2, (m/II) large subunit
    XP_005622713.1
666 aa
   CAPN2,  B.taurus
calpain 2, (m/II) large subunit
    NP_001096556.1
700 aa
   Capn2,  M.musculus
calpain 2
    NP_033924.2
700 aa
   Capn2,  R.norvegicus
calpain 2, (m/II) large subunit
    NP_058812.1
700 aa
   CAPN2,  G.gallus
calpain 2, (m/II) large subunit
    NP_990411.1
700 aa
   capn2.2,  X.tropicalis
calpain 2, (m/II) large subunit
    NP_001005446.1
699 aa
   zgc:92480,  D.rerio
zgc:92480
    NP_001003485.1
700 aa
   capn2l,  D.rerio
calpain 2, (m/II) large subunit, like
    NP_001017807.1
700 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.
Jeong SY, et al. Proc Natl Acad Sci U S A 110, E4007-15 (2013).
RVG-mediated calpain2 gene silencing in the brain impairs learning and memory.
Zadran S, et al. Neuromolecular Med 15, 74-81 (2013).
m-Calpain activation in vitro does not require autolysis or subunit dissociation.
Chou JS, et al. Biochim Biophys Acta 1814, 864-72 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EF_hand_6 (pfam13833)
  EF-hand domain pair.
FRQ1 (COG5126)
  Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only].
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
EFh (cl17302)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
CysPc (cl00051)
  Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
Calpain_III (cl00165)
  Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
EF-hand_8 (cl17302)
  EF-hand domain pair.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Capn2 includes H.sapiens CAPN2 and R.norvegicus Capn2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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