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HomoloGene:36349. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ARHGAP26,  H.sapiens
Rho GTPase activating protein 26
    NP_055886.1
814 aa
   ARHGAP26,  P.troglodytes
Rho GTPase activating protein 26
    XP_001154393.1
814 aa
   ARHGAP26,  M.mulatta
Rho GTPase activating protein 26
    XP_001096464.2
759 aa
   ARHGAP26,  C.lupus
Rho GTPase activating protein 26
    XP_535224.4
815 aa
   ARHGAP26,  B.taurus
Rho GTPase activating protein 26
    NP_001192451.1
815 aa
   Arhgap26,  M.musculus
Rho GTPase activating protein 26
    NP_780373.3
814 aa
   Arhgap26,  R.norvegicus
Rho GTPase activating protein 26
    NP_001100859.1
761 aa
   ARHGAP26,  G.gallus
Rho GTPase activating protein 26
    NP_990525.2
760 aa
   arhgap26,  X.tropicalis
Rho GTPase activating protein 26
    NP_001120245.2
759 aa
   Graf,  D.melanogaster
Graf
    NP_996441.1
1016 aa
   AgaP_AGAP013143,  A.gambiae
AgaP_AGAP013143
    XP_003436889.1
589 aa
   T04C9.1,  C.elegans
T04C9.1
    NP_741163.2
881 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, juvenile myelomonocytic.



Publications
Articles associated with genes and sequences of this homology group.

Dissecting the thermodynamics of GAP-RhoA interactions.
Jelen F, et al. J Struct Biol 165, 10-8 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Arhgap26 includes H.sapiens ARHGAP26 and R.norvegicus Arhgap26.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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