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HomoloGene:901. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   XIAP,  H.sapiens
X-linked inhibitor of apoptosis
    NP_001158.2
497 aa
   XIAP,  P.troglodytes
X-linked inhibitor of apoptosis
    XP_529138.2
497 aa
   XIAP,  C.lupus
X-linked inhibitor of apoptosis
    XP_005641830.1
493 aa
   XIAP,  B.taurus
X-linked inhibitor of apoptosis
    NP_001192521.1
497 aa
   Xiap,  M.musculus
X-linked inhibitor of apoptosis
    NP_033818.2
496 aa
   Xiap,  R.norvegicus
X-linked inhibitor of apoptosis
    NP_071567.1
496 aa
   XIAP,  G.gallus
X-linked inhibitor of apoptosis
    NP_989919.1
493 aa
   xiap,  X.tropicalis
X-linked inhibitor of apoptosis
    NP_001025583.1
492 aa
   xiap,  D.rerio
X-linked inhibitor of apoptosis
    NP_919377.2
405 aa
   IAP3,  A.gambiae
IAP3
    XP_308528.2
330 aa
   IAP7,  A.gambiae
IAP7
    XP_001237095.2
341 aa
   IAP4,  A.gambiae
IAP4
    XP_308529.3
335 aa
   AgaP_AGAP012677,  A.gambiae
AgaP_AGAP012677
    XP_560812.1
150 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Lymphoproliferative syndrome, X-linked, 2.



Publications
Articles associated with genes and sequences of this homology group.

The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Lukacs C, et al. Acta Crystallogr D Biol Crystallogr 69, 1717-25 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
zf-C3HC4_3 (pfam13920)
  Zinc finger, C3HC4 type (RING finger).
BIR (cl00035)
  Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Xiap includes H.sapiens XIAP and R.norvegicus Xiap.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

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