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HomoloGene:88935. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NLRC5,  H.sapiens
NLR family, CARD domain containing 5
    NP_115582.4
1866 aa
   NLRC5,  P.troglodytes
NLR family, CARD domain containing 5
    XP_003952898.1
1864 aa
   NLRC5,  M.mulatta
NLR family, CARD domain containing 5
    XP_001095341.2
1730 aa
   NLRC5,  C.lupus
NLR family, CARD domain containing 5
    XP_544394.4
1867 aa
   NLRC5,  B.taurus
NLR family, CARD domain containing 5
    XP_002694836.1
1868 aa
   Nlrc5,  M.musculus
NLR family, CARD domain containing 5
    NP_001028379.2
1915 aa
   NLRC5,  G.gallus
NLR family, CARD domain containing 5
    XP_004944113.1
1861 aa
   LOC101730474,  X.tropicalis
protein NLRC5-like
    XP_004914291.1
653 aa
   si:ch211-122c9.5,  D.rerio
si:ch211-122c9.5
    XP_003200494.2
1746 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity.
Meissner TB, et al. Biochem Biophys Res Commun 418, 786-91 (2012).
Regulation of immune pathways by the NOD-like receptor NLRC5.
Lamkanfi M & Kanneganti TD. Immunobiology 217, 13-6 (2012).
Cutting edge: NLRC5-dependent activation of the inflammasome.
Davis BK, et al. J Immunol 186, 1333-7 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Mg_chelatase (pfam01078)
  Magnesium chelatase, subunit ChlI.
LRR_8 (pfam13855)
  Leucine rich repeat.
NACHT (pfam05729)
  NACHT domain.
LRR_RI (cd00116)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
LRR_RI (cl15309)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
LRR_8 (pfam13855)
  Leucine rich repeat.
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nlrc5 includes H.sapiens NLRC5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 5 species)

 

 

 

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