Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:3760. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NR1H4,  H.sapiens
nuclear receptor subfamily 1, group H, member 4
    NP_001193922.1
486 aa
   NR1H4,  P.troglodytes
nuclear receptor subfamily 1, group H, member 4
    XP_509299.2
482 aa
   NR1H4,  M.mulatta
nuclear receptor subfamily 1, group H, member 4
    XP_001090182.1
482 aa
   NR1H4,  C.lupus
nuclear receptor subfamily 1, group H, member 4
    XP_852959.2
476 aa
   NR1H4,  B.taurus
nuclear receptor subfamily 1, group H, member 4
    NP_001029880.1
482 aa
   Nr1h4,  M.musculus
nuclear receptor subfamily 1, group H, member 4
    NP_001157172.1
488 aa
   Nr1h4,  R.norvegicus
nuclear receptor subfamily 1, group H, member 4
    NP_068513.1
469 aa
   NR1H4,  G.gallus
nuclear receptor subfamily 1, group H, member 4
    NP_989444.1
473 aa
   nr1h4,  X.tropicalis
nuclear receptor subfamily 1, group H, member 4
    XP_002936891.2
478 aa
   nr1h4,  D.rerio
nuclear receptor subfamily 1, group H, member 4
    NP_001002574.1
483 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice.
Zhang X, et al. Proc Natl Acad Sci U S A 111, 2277-82 (2014).
Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?
Baptissart M, et al. Cell Mol Life Sci 70, 4511-26 (2013).
Regulation of N-Myc downstream regulated gene 2 by bile acids.
Langhi C, et al. Biochem Biophys Res Commun 434, 102-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nr1h4 includes H.sapiens NR1H4 and R.norvegicus Nr1h4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (13 transcripts, 8 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

Write to the Help Desk